Yes, hot swapping is possible. Hardware can safely and elegantly move in and out of the tank because of the fluid's low boiling temperature (ie. 49°C).
When hardware is pulled out of the liquid and moves up through the vapor into the headspace with air, it is usually already dry. In other words, hardware leaves the tank dry.
Novec™ Engineered Fluids are extremely clean, they are not greasy, oily or sticky, there will be no residue.